Metabolism Alprazolam is thoroughly metabolized in human beings, mainly by cytochrome P450 3A4 (CYP3A4), to two main Lively metabolites while in the plasma: four-hydroxyalprazolam and ?-hydroxyalprazolam. The plasma circulation levels of the two Energetic metabolites are less than 4% on the father or mother. The noted relative potencies in benzodia